Trans-Resveratrol and Longevity: Here’s What You Need to Know

Trans-Resveratrol and Longevity: Here’s What You Need to Know

Since its discovery in 1939, resveratrol rose to prominence in the early 2000s, celebrated for its contribution to heart health through practices like moderate wine consumption, owing to its anti-inflammatory effects. Yet, the past two decades have seen this enthusiasm tempered by rigorous scrutiny and mixed results from clinical studies, raising questions about resveratrol's absorption efficiency through the digestive system.

Presently, research on resveratrol has evolved, offering a broader perspective on its versatile health benefits. Beyond its initial recognition for heart health, recent studies highlight its promise in neuroprotection, cognitive enhancement, and longevity, attributed to its activation of genes that guard against age-related diseases. Furthermore, resveratrol is investigated for its anti-proliferative qualities, capable of hindering the spread of abnormal cells and triggering their elimination. As research progresses, resveratrol's potential in natural health therapies continues to be a focal point.

Nonetheless, not all resveratrol supplements are equal. A pivotal realization in longevity research is that trans-resveratrol, the most active form, is responsible for resveratrol's health benefits.


Understanding Resveratrol and Its Functioning

Resveratrol is a stilbenoid and phytoalexin produced by plants in response to stress, possessing a range of biological activities, including anti-inflammatory, anti-proliferative, and antioxidant effects. It's found in grape skins, berries, and nuts.


Distinguishing Cis-Resveratrol from Trans-Resveratrol

Resveratrol exists in two isomers:

  • Cis-resveratrol, which has minimal health benefits due to poor bioavailability.
  • Trans-resveratrol, the bioactive form that's more efficiently absorbed and utilized by the body, offering the majority of health benefits associated with resveratrol.

Four Key Benefits of Trans-Resveratrol

  • Synergy with NMN: Enhances lifespan and mitigates metabolic diseases by activating sirtuins, thus regulating cellular health.
  • Powerful Antioxidant: Protects against oxidative stress, supports healthy blood pressure and sugar levels, and reduces cardiovascular disease risk.
  • Natural Anti-Inflammatory: Helps in various conditions, including preventing joint damage and cartilage breakdown.
  • Antimicrobial Properties: Effective against bacteria and fungi, showing promise in treating urinary tract infections by disrupting pathogen biofilms.

Trans-resveratrol may inhibit the proliferation of bacteria such as E. Coli, and fungi such as Candida albicans. A 2019 study found that trans-resveratrol and the resveratrol derivative oxyresveratrol may be effective against uropathogenic Escherichia coli (UPEC). E. Coli is the main causative agent in urinary tract infections (UTI) and has been shown to persist even with antibiotic treatment. The ability of trans-resveratrol to diminish pathogen-protective biofilms, leading to the killing of UPEC, warrants further attention into the role of trans-resveratrol as an antimicrobial agent.

Choosing a Resveratrol Supplement

Look for supplements with at least 98% pure trans-resveratrol and consider those with absorption-enhancing ingredients like quercetin or piperine to maximize bioavailability.

  • Absorption enhancing blends
    Regular resveratrol containing cis-resveratrol is 1% absorbable. Additions to pure trans-resveratrol supplements, such as quercetin, red wine extract, green tea extract, and BioPerine®, have been shown to improve absorption. For example, one study demonstrated an increase of resveratrol of up to 1544% from 229% after the inclusion of piperine, a black pepper derivative. BioPerine® is a product sourced out of piperine and is the only one to obtain a patented status for increasing bioavailability of nutritional compounds. 


Safety Considerations

While trans-resveratrol is generally safe, high doses may cause side effects. It's important to consult a healthcare provider before starting supplementation, especially when pregnant, estrogen-sensitive, or taking certain medications.



Trans-resveratrol offers significant potential for extending healthspan by maintaining cellular health and combating oxidative damage. When paired with NMN, it forms a powerful duo for supporting long-term health and vitality.

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